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1.
Sci Rep ; 14(1): 6652, 2024 03 20.
Artigo em Inglês | MEDLINE | ID: mdl-38509137

RESUMO

Osteochondral damage (OD) is a significant outcome following acute patellar dislocation (APD), yet the factors contributing to its susceptibility remain unclear. The primary objective of this study was to assess the association between demographic characteristics, patellofemoral (PF) joint morphology, and the occurrence of OD. A retrospective analysis identified 74 patients with APD who underwent treatment in our unit between 2019 and 2022. All patients received MRI within a week of injury to assess OD, subsequently categorized according to the injury pattern. The Caton-Deschamps index (CDI), tibial tuberosity-trochlear groove distance (TT-TG), lateral trochlear inclination (LTI), sulcus angle (SA), patellar width (PW), patellar thickness (PT), and femoral condyle geometry were calculated from the MRI scans and compared between groups. The findings revealed that OD predominantly manifested in the lateral femoral condyle (LFC) region and the medial patella (MP) region. In our patient cohort, this study identified a significant association between sulcus angle and the incidence of OD in both MP and LFC regions. Additionally, a significant correlation was discerned between skeletal maturity and the incidence of OD in the LFC region within demographic characteristics.


Assuntos
Fraturas Intra-Articulares , Luxação Patelar , Articulação Patelofemoral , Humanos , Patela/diagnóstico por imagem , Estudos Retrospectivos , Luxação Patelar/diagnóstico por imagem , Luxação Patelar/epidemiologia , Articulação Patelofemoral/diagnóstico por imagem , Tíbia/diagnóstico por imagem , Fatores de Risco
2.
Acta Orthop ; 95: 14-19, 2024 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-38240376

RESUMO

BACKGROUND AND PURPOSE: We aimed to calculate the prevalence of patellar dislocation (PD) and trochlear dysplasia (TD) in a national cohort aged 15-19 years in the Faroe Island. PATIENTS AND METHODS: All inhabitants in the Faroe Islands aged 15-19 years were invited to answer an online survey, including demographics and questions regarding prior PD. Participants with prior PD were invited for radiographs and MRI of both knees to be taken. Trochlear dysplasia was defined as one of the following: Dejour type A-D on radiographs, lateral trochlear inclination angle (LTI) < 11°, or trochlear depth < 3 mm on MRI. RESULTS: 3,749 individuals were contacted, 41 were excluded, and 1,638 (44%) completed the survey. 146 reported a prior PD (the PD cohort) and 100 accepted to participate and have radiographs and MRI taken of both knees (the clinical PD cohort), 76 of whom were diagnosed with TD. The national prevalence of PD was 8.9%. The national prevalence of symptomatic TD was 6.8%. The prevalence of TD in the clinical PD cohort was 76%. TD was bilateral in 78% of TD patients, but only 27% of patients with bilateral TD had PD in both knees. CONCLUSION: The prevalence of PD in the Faroe Islands is found to be very high. The national prevalence of TD and the prevalence of TD in participants with prior PD is high, indicating a potential genetic influence.


Assuntos
Instabilidade Articular , Luxação Patelar , Articulação Patelofemoral , Humanos , Estudos de Coortes , Fêmur , Articulação do Joelho/diagnóstico por imagem , Luxação Patelar/diagnóstico por imagem , Luxação Patelar/epidemiologia , Articulação Patelofemoral/diagnóstico por imagem , Prevalência , Adolescente , Adulto Jovem
3.
Orthop Surg ; 16(2): 437-443, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38214094

RESUMO

OBJECTIVE: Systematic summary of the epidemiology of patellar dislocation is rare. This study aims to investigate sex-, age-, type-, injury causing events-, incidence of bone bruise and time from last injury (TFLI)-specific characteristics, and detail the epidemiological characteristics of patellar dislocation. METHOD: In this descriptive epidemiological study, a total of 743 patients who have a history of lateral patellar dislocation with either first-time patellar dislocation (FPD) or recurrent patellar dislocation (RPD) between August 2017 and June 2022 at our institution met the inclusion criteria and were selected in this study. Patient characteristics including the type, gender, age, events leading to patellar dislocation, incidence of patellar bone bruise, and the time from last injury (TFLI) of patellar dislocation were retrospectively obtained and described. Magnetic resonance imaging scans (MRI) of the knee were reviewed for insuring bone bruise. RESULTS: Among the 743 patients with patellar dislocation who required surgical reconstruction of the medial retinaculum, 418 (56.2%) had RPD and 325 (43.8%) had FPD. There were more females (65.0%) than males (35.0%) in patellar dislocation patients. Among the female patients, those aged <18 years had higher incidence (31.4%) of patellar dislocation. Among the male patients, those aged <18 and 19-28 years had higher incidence (16.8%) of patellar dislocation. Of all age groups, the prevalence rate of patellar dislocation was high in juvenile population and females, but with no statistical significance. The most common patellar dislocation-causing event was sport accidents (40.1%), followed by life accidents (23.2%). The incidence of left-knee patellar dislocation was slightly higher than that of right-knee patellar dislocation. The incidence of patellar bone bruise of RPD (63.2%) was significantly lower (p < 0.05) than that of FPD (82.2%). Patellar dislocation patients with bone bruise had shorter time from last injury (TFLI) than those without patellar bone bruise (p < 0.05). CONCLUSIONS: The incidence of bone bruise of RPD was lower than that of FPD, and patients with patellar bone bruise may have a shorter time from last injury than those without bone bruise.


Assuntos
Contusões , Luxação Patelar , Humanos , Masculino , Feminino , Luxação Patelar/diagnóstico por imagem , Luxação Patelar/epidemiologia , Centros de Traumatologia , Estudos Retrospectivos , Articulação do Joelho/patologia , Contusões/epidemiologia , Contusões/patologia
4.
Sports Health ; 16(3): 465-472, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-37208906

RESUMO

BACKGROUND: Vitamin D has been proven experimentally to affect musculoskeletal health. The purpose of this study was to identify the relationship between vitamin D deficiency and patellar instability. HYPOTHESIS: Vitamin D deficiency is associated with an increased risk of experiencing primary patellar instability and recurrent patellar dislocation after primary surgical stabilization. STUDY DESIGN: Retrospective comparative study. LEVEL OF EVIDENCE: Level 3. METHODS: A 1:1 matched retrospective study of 328,011 patients diagnosed with vitamin D deficiency was performed using the PearlDiver database. Incidence of primary patellar instability was calculated according to sex and age. Rates of primary patellar instability and surgical stabilization for recurrent dislocation were calculated with sex- and age-specific stratifications. Multivariable logistic regression was used to compare the rates of primary injury and recurrent stabilization while controlling for demographics and medical comorbidities. RESULTS: A total of 656,022 patients were analyzed. The overall 1-year incidence rate of patellar instability in patients with vitamin D deficiency was 82.6 per 100,000 person-years (95% CI, 73.2-92.9), compared with 48.5 (95% CI, 41.4-56.5) in the matched control. Women were significantly more likely to experience primary patellar instability within 1 (adjusted odds ratio [aOR] = 1.45; 95% CI, 1.12-1.88) and 2 years (aOR, 1.31; 95% CI, 1.07-1.59) of hypovitaminosis D diagnosis. Patients aged 10 to 25 years with hypovitaminosis D were at greater risk of requiring recurrent patellar stabilization for both men (aOR, 2.48; 95% CI, 1.06-5.80) and women (aOR, 1.77; 95% CI, 1.04-3.02). CONCLUSION: Patients diagnosed with vitamin D deficiency experienced higher rates of primary patellar instability and have greater risk of requiring recurrent surgical stabilization for subsequent dislocations. CLINICAL RELEVANCE: These results suggest that monitoring and proactively treating vitamin D deficiency in the physically active patient may lower the risk of suffering primary patellar instability or recurrence after surgical stabilization.


Assuntos
Luxações Articulares , Instabilidade Articular , Luxação Patelar , Articulação Patelofemoral , Deficiência de Vitamina D , Masculino , Humanos , Feminino , Estudos Retrospectivos , Luxação Patelar/epidemiologia , Instabilidade Articular/epidemiologia , Instabilidade Articular/cirurgia , Recidiva , Deficiência de Vitamina D/complicações , Deficiência de Vitamina D/epidemiologia
5.
BMC Musculoskelet Disord ; 24(1): 933, 2023 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-38041089

RESUMO

BACKGROUND: Posterior cruciate ligament (PCL) injuries are common ligament injuries of the knee, and previous studies often focused on the associations between the morphology of the knee and PCL injuries. Studies on the correlation between PCL injuries and patellofemoral alignment are limited. METHODS: This retrospective study included 92 patients with PCL injured and 92 patients with PCL intact. Measurement parameters were compared between the two groups, including patellar tilt angle, congruence angle, patellar height, hip-knee-ankle angle, lateral trochlear inclination, femoral condyle ratio, bicondylar width, intercondylar notch width and index, notch angle, trochlear facet asymmetry, and trochlear sulcus depth and angle. Independent risk factors associated with PCL injuries were identified by logistic regression analyses. RESULTS: In the PCL injured group, the patellar tilt angle was significantly larger (13.19 ± 5.90° vs. 10.02 ± 4.95°, P = 0.04); the intercondylar notch angle was significantly lower (60.97 ± 7.83° vs. 67.01 ± 6.00°, P = 0.004); the medial and lateral femoral condyle ratio were significantly larger (0.63 ± 0.64 vs. 0.60 ± 0.56, P = 0.031; 0.65 ± 0.60 vs. 0.58 ± 0.53, P = 0.005) than in the PCL intact group. There were 11 patients with patellar dislocation in the PCL injured group, accounting for 12%. In these patients, the patellar height was higher (1.39 ± 0.17 vs. 1.09 ± 0.25, P = 0.009); the trochlear sulcus angle was larger (157.70 ± 8.7° vs. 141.80 ± 8.78°, P < 0.001); and the trochlear sulcus depth was shallower (3.10 ± 1.20mm vs. 5.11 ± 1.48mm, P = 0.003) than those in the patients without patellar dislocation. Multivariate analyses showed that patellar tilt angle (each increase 1 degree, OR = 1.14) and intercondylar notch angle (each increase 1 degree, OR = 0.90) were independent risk factors for PCL injuries. CONCLUSION: The patients with PCL injuries had larger patellar tilt angles, lower intercondylar notch angles, and longer posterior femoral condyles than patients with PCL intact. The larger patellar tilt angle and lower intercondylar notch angle might be risk factors for PCL injuries.


Assuntos
Luxação Patelar , Ligamento Cruzado Posterior , Humanos , Ligamento Cruzado Posterior/diagnóstico por imagem , Estudos Retrospectivos , Luxação Patelar/diagnóstico por imagem , Luxação Patelar/epidemiologia , Luxação Patelar/etiologia , Articulação do Joelho/diagnóstico por imagem , Patela/diagnóstico por imagem , Imageamento por Ressonância Magnética
6.
J Orthop Surg Res ; 18(1): 822, 2023 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-37915023

RESUMO

PURPOSE: The purpose of the study was to summarize the available evidence and identify risk factors for osteochondral injuries (OCIs) after patellar dislocations. METHODS: A systematic literature review was conducted in PubMed, Embase, Web of Science, Cochrane Library, and China national knowledge infrastructure from inception to December 22, 2022, according to the preferred reporting items for systematic reviews and meta-analyses guidelines. Studies regarding risk factors for OCIs after patellar dislocations were included. Literature search, data extraction, and quality assessment were performed independently by two authors. RESULTS: A total of 16 studies with 1945 patients were included. The risk factors for OCIs after patellar dislocation were categorized into four main categories, including demographic characteristics, patellar depth and position, femoral trochlear morphology, and other risk factors in this study. Five and three studies supported the idea that male sex and skeletal maturation may be risk factors, respectively. Normal femoral trochlea (two studies) and complete medial patellofemoral ligament (MPFL) injuries (two studies) may be associated with the development of OCIs. Three studies show that ligamentous laxity or joint hypermobility may prevent OCIs. Patellar depth and position (eight studies) may not be associated with the development of OCIs. CONCLUSIONS: Based on the available evidence, an increased risk of OCIs following patellar dislocation may be associated with male sex and skeletal maturation. Furthermore, normal femoral trochlea and complete MPFL injuries may increase the risk of OCIs, while factors such as ligamentous laxity or joint hypermobility may reduce the risk. LEVEL OF EVIDENCE: Level IV, systematic review of Level II and IV studies.


Assuntos
Fraturas Intra-Articulares , Instabilidade Articular , Luxação Patelar , Articulação Patelofemoral , Humanos , Masculino , Luxação Patelar/complicações , Luxação Patelar/epidemiologia , Instabilidade Articular/etiologia , Patela/lesões , Articulação do Joelho , Fêmur , Ligamentos Articulares/lesões , Fraturas Intra-Articulares/complicações , Fatores de Risco
7.
Prev Vet Med ; 220: 106034, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37801966

RESUMO

Patellar luxation (PL) is a common orthopaedic condition in dogs. This study aimed to evaluate the incidence and cause-specific mortality rate, age at diagnosis, and risk factors for medial PL (MPL), lateral PL (LPL), and bidirectional PL (BPL). Other diagnoses in dogs with PL were also explored. The study population included just over 600,000 dogs insured by Agria Pet Insurance in Sweden (2011-2016). There were 2726 dogs with PL. Medial patellar luxation affected 90 % of the dogs with PL, followed by LPL (5.9 %), BPL (2.4 %), and unspecified PL (1.6 %). The median age at first diagnosis during the study period was 2.8 years for MPL, 2.7 years for LPL, and 1.5 years for BPL. In total, 168 (6.2 %) of the dogs with PL had cruciate ligament rupture. There were substantial breed-specific differences in the risk of PL: almost all breeds at increased risk of MPL were small-sized, while several of the breeds at increased risk of LPL were large-sized. The breeds at high risk of BPL varied in size. Females had an increased risk of MPL (RR 1.2, 95 % CI: 1.1-1.3, p < 0.001) and a decreased risk of LPL (RR 0.72, 95 % CI: 0.51-1.0, p = 0.042) compared to males. In total, 116 dogs were euthanised due to PL and the breeds with the highest risk of PL-related euthanasia were the Pyrenean mountain dog, Dogue de Bordeaux, and German pinscher. The median age for PL-related euthanasia was 2.2 years.


Assuntos
Doenças do Cão , Luxação Patelar , Humanos , Masculino , Feminino , Cães , Animais , Suécia/epidemiologia , Doenças do Cão/epidemiologia , Doenças do Cão/genética , Eutanásia Animal , Luxação Patelar/epidemiologia , Luxação Patelar/veterinária , Cruzamento
8.
Knee Surg Sports Traumatol Arthrosc ; 31(9): 3806-3846, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36854995

RESUMO

PURPOSE: The aim of the study was to perform a systematic review and best knowledge synthesis of the present literature concerning biomechanical risk factors for developing first-time and recurrent patella dislocation. METHODS: The study was performed as a systematic review following PRISMA guidelines. PubMed and EMBASE were systematically searched. Studies investigating participants with risk factors for first-time as well as recurrent patella dislocation were included. The records were screened, and data extracted independently by two researchers supervised by a third independent assessor. The study was registered in PROSPERO. RESULTS: A total of 6233 records were screened, and 50 studies met the inclusion criteria. The biomechanical risk factors: trochlear dysplasia, increased tibial tuberosity-trochlear groove distance (TT-TG), and patella alta were found to be statistically significantly associated with patella dislocation in several publications and were thus recognized as risk factors for patella dislocation. The soft-tissue stabilizers: longer and thinner MPFL ligament, increased number of type 2C and decreased number of type 1 muscle fibers, and joint laxity were found to be statistically significantly associated with patella dislocation in a few publications, but due to limited evidence, no conclusion was made on this matter. CONCLUSION: There is strong evidence in the literature that abnormalities of bony stabilizers, trochlear dysplasia, increased TT-TG distance, and patella alta are risk factors for patella dislocation. There is less evidence that soft-tissue stabilizers are risk factors. The study emphasizes the importance of a thorough investigation of bony stabilizers in clinical decision-making. LEVEL OF EVIDENCE: Level IV.


Assuntos
Luxações Articulares , Instabilidade Articular , Luxação Patelar , Articulação Patelofemoral , Humanos , Patela/diagnóstico por imagem , Articulação Patelofemoral/diagnóstico por imagem , Luxação Patelar/epidemiologia , Tíbia , Ligamentos Articulares , Fatores de Risco , Estudos Retrospectivos
9.
Acta Radiol ; 64(5): 1934-1942, 2023 May.
Artigo em Inglês | MEDLINE | ID: mdl-36740851

RESUMO

BACKGROUND: The injury characteristics of medial patellofemoral ligament (MPFL) in multiligament knee injuries (MLKIs) and the differences of injury patterns of MPFL in MLKIs and acute lateral patellar dislocation (LPD) remain unclear. PURPOSE: To explore the differences of injury characteristics of MPFL after acute LPD and MLKIs. METHODS: Magnetic resonance images were prospectively analyzed in 219 patients after acute LPD or MLKIs. Statistical analyses of the injury patterns of MPFL were performed between LPD and MLKIs. RESULTS: The incidence of partial tear and complete MPFL tear in adolescent LPD and MLKIs were 40.3% and 48.4%, and 27.9% and 16.3%, respectively. Compared with LPD, MLKIs showed lower incidence rates of partial and complete MPFL tears (both P = 0). The MLKI subgroup showed lower incidence rates of MPFL tear at the patellar insertion (PAT), femoral attachment (FEM), and multiple-site of the MPFL (COM) (9.3%, 20.9%, and 14%) when compared with the LPD subgroup (45.2%, 24.2%, and 16.1%) (all P < 0.01). The incidence of partial tear and complete MPFL tear in adult LPD and MLKIs were 41.5% and 47.2%, and 24.6% and 16.4%, respectively. Compared with LPD, MLKIs showed lower incidence rates of partial and complete MPFL tears (both P = 0). The MLKI subgroup showed lower incidence rates of MPFL tear at PAT, FEM, and COM (8.2%, 18%, and 14.8%) when compared with the LPD subgroup (20.8%, 34%, and 30.2%) (all P = 0). CONCLUSION: Compared with LPD, MPFL tears are relatively uncommon in MLKIs. Even if MPFL tears occur, partial tears and femoral-sided tears are relatively more common.


Assuntos
Traumatismos do Joelho , Luxação Patelar , Adulto , Adolescente , Humanos , Luxação Patelar/diagnóstico por imagem , Luxação Patelar/epidemiologia , Luxação Patelar/etiologia , Traumatismos do Joelho/diagnóstico por imagem , Traumatismos do Joelho/epidemiologia , Articulação do Joelho , Ligamentos Articulares/diagnóstico por imagem , Ligamentos Articulares/lesões , Ruptura
10.
Int Orthop ; 47(4): 973-981, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-36749375

RESUMO

PURPOSE: To present age- and sex-specific cumulative annual incidences of primary traumatic lateral patellar dislocation (LPD) and to detail patient characteristics and concomitant chondral injuries including osteochondral fractures, as visualized on magnetic resonance imaging (MRI), in a large consecutive cohort of knee-injured individuals. METHODS: Data on primary traumatic lateral patellar dislocations were collected from a large consecutive cohort of knee injuries examined with sub-acute MRI in a single centre with a well-defined catchment area. Annual incidences for different age-groups in relation to gender were calculated together with the risk of concomitant chondral and osteochondral injury, during sports and in general. RESULTS: A total of 184 primary patellar dislocations were identified in the cohort of 1145 acute knee injuries (n=175) and surgical records (n=9). Knee MRI was performed within a median of six days of injury. Median age of patients with primary LPD was 16 years (interquartile range, 14-21; range, 9-47) and 41% were females. Males were significantly older than females at the time of injury (median age 17 vs. 15, P = 0.021) and sustained their primary LPD during sports more often than females (65 vs. 40%, P < 0.001). Primary LPD occurred most frequently at the age of 13 to 15 years where the annual incidence was 125 (95% CI, 96-160) per 100,000 persons. The overall annual incidence of primary LPD was 14 (95% CI, 12-16) per 100,000 persons, with a predominance of males versus females (17 vs. 11, P = 0.01). Concomitant lesions to joint surfaces were displayed on MRI or during surgery in 75 (43%) knees. Osteochondral fractures were seen in 32 knees (18%). We found no statistically significant difference in the risk of osteochondral fracture between those injured during sports or during leisure activity (14 vs. 24%, P = 0.08). CONCLUSIONS: The annual incidence of first-time patellar dislocation was found to be 14 per 100,000 individuals with the highest incidence found among those aged 13-15 years. Primary LPD was more common among males and was sustained during sports activity in 55% of the cases. Associated injuries to the chondral surfaces should be expected in 43% of knees with primary LPD where 18% represent osteochondral fractures.


Assuntos
Fraturas Intra-Articulares , Traumatismos do Joelho , Luxação Patelar , Masculino , Feminino , Humanos , Adolescente , Luxação Patelar/diagnóstico por imagem , Luxação Patelar/epidemiologia , Incidência , Traumatismos do Joelho/complicações , Traumatismos do Joelho/diagnóstico por imagem , Traumatismos do Joelho/epidemiologia , Articulação do Joelho/diagnóstico por imagem , Articulação do Joelho/patologia , Patela/lesões , Imageamento por Ressonância Magnética/métodos
11.
Knee Surg Sports Traumatol Arthrosc ; 31(9): 3701-3733, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36629887

RESUMO

PURPOSE: The aim of our study was to perform a systematic review and best knowledge synthesis of the present literature concerning the familial association and epidemiological factors as risk factors for developing first-time and recurrent patella dislocation. METHODS: The study was conducted according to the PRISMA guidelines and registered in PROSPERO. EMBASE and PubMed were systematically searched on the 5th of May 2022. Studies investigating participants with genetic and epidemiological risk factors for the first time as well as recurrent patella dislocation were included. The records were screened, and data were extracted independently by two researchers supervised by a third independent assessor. RESULTS: A total of 6,649 records were screened, and 67 studies were included. Familial association was described as a risk factor for patella dislocation in 17 studies. One study found that participants with a family history of patella dislocation had a 3.7 higher risk for patella dislocation in the contralateral asymptomatic knee, and another study found a family history of PD in 9% of 74 participants. Eleven studies found an accumulation of patella dislocation across generations in specific families. Additionally, a range of genetic syndromes was associated with patella dislocation. Young age is a well-investigated risk factor for patella dislocation, but the results are inconsistent. Only five and eight studies investigated skeletal immaturity and gender as risk factors for patella dislocation, respectively. CONCLUSION: There may be a familial association with patella dislocation, but further investigation is necessary to determine the strength and etiology of the association. There is weak evidence that epidemiological risk factors, such as age, skeletal immaturity, gender, and BMI are risk factors for patella dislocation. LEVEL OF EVIDENCE: IV.


Assuntos
Luxações Articulares , Luxação Patelar , Humanos , Patela , Recidiva , Luxação Patelar/epidemiologia , Luxação Patelar/genética , Fatores de Risco , Articulação do Joelho
12.
Clin Sports Med ; 41(4): 627-651, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-36210163

RESUMO

This article summarizes the latest research related to pediatric patellar instability. The epidemiology, patterns of patellar instability, and underlying pathoanatomy are unique in children and adolescents. Information related to the natural history and predictive factors of patellar instability in young patients would allow for better patient counseling and management decisions. The components of nonoperative treatment for first patellar dislocation are outlined. Physeal-respecting surgical techniques, including medial patellofemoral ligament reconstruction in skeletally immature patients, are discussed. The indications and outcomes for quadricepsplasty to address more complex instability patterns are presented. Evaluation and management strategies for specific anatomic risk factors is provided.


Assuntos
Instabilidade Articular , Luxação Patelar , Articulação Patelofemoral , Adolescente , Atletas , Criança , Humanos , Instabilidade Articular/diagnóstico , Instabilidade Articular/epidemiologia , Instabilidade Articular/cirurgia , Ligamentos Articulares/cirurgia , Luxação Patelar/diagnóstico , Luxação Patelar/epidemiologia , Luxação Patelar/cirurgia , Articulação Patelofemoral/cirurgia
13.
BMC Med Genomics ; 15(1): 176, 2022 08 07.
Artigo em Inglês | MEDLINE | ID: mdl-35934709

RESUMO

BACKGROUND: Recurrent patellar dislocation is the result of anatomical alignment and imbalance of restraint of bone and soft tissue. We investigate the anatomical characteristics of the knee joint in a family of patients with recurrent patella dislocation, and to screen the possible pathogenic genes in this family by whole exome sequencing in 4 patients and 4 healthy subjects, so as to provide theoretical basis for the pathogenesis of this disease. METHODS: The data related to patella dislocation were measured by imaging data. The peripheral blood DNA of related family members was extracted for the whole exome sequencing, and then the sequencing results were compared with the human database. By filtering out synonymous variants and high-frequency variants in population databases, and then integrating single nucleotide non-synonymous variants of family members, disease-causing genes were found. RESULTS: All patients in this family have different degrees of abnormal knee anatomy, which is closely related to patella dislocation. The sequencing results of patients and normal persons in this patella dislocation family were compared and analyzed, and the data were filtered through multiple biological databases. Find HOXB9 (NM_024017.4:c.404A>G:p.Glu135Gly),COL1A1(NM_000088.3:c.3766G>A:p.Ala1256Thr),GNPAT(NM_014236.3:c1556A>G:p.Asp519Gly),NANS(NM_018946.3:c.204G>C:p.Glu68Asp),SLC26A2(NM_000112.3:c.2065A>T:p.Thr689Ser) are nonsynonymous variants (MISSENSE). Through Sanger sequencing, the identified mutations in HOXB9 and SLC26A2 genes were only present in samples from patients with recurrent patellar dislocation. CONCLUSIONS: The patients with recurrent patellar dislocation had markedly abnormal knee anatomy in this family. HOXB9 gene and SLC26A2 gene were found to be the possible pathogenic genes or related genes for patella dislocation.


Assuntos
Luxação Patelar , Diagnóstico por Imagem , Proteínas de Homeodomínio/genética , Humanos , Articulação do Joelho , Mutação , Patela/patologia , Luxação Patelar/epidemiologia , Luxação Patelar/genética , Luxação Patelar/patologia , Recidiva
14.
Am J Sports Med ; 50(2): 471-477, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35060768

RESUMO

BACKGROUND: Predicting the risk of recurrence is of great interest when counseling patients after primary lateral patellar dislocation (LPD). PURPOSE: To investigate a multivariate model to predict the individual risk of recurrent LPD. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: The study population included patients with primary LPD, knee imaging, and a minimum 2-year follow-up after nonoperative treatment. Data including patient characteristics and anatomic patellar instability risk factors were collected retrospectively from 7 national study centers. Bivariate and multivariate regression analyses were carried out to identify risk factors for recurrent LPD and to generate an accuracy-optimized model for out-of-sample prediction. RESULTS: In total, 115 of 201 patients (57%) experienced recurrent LPD within 2 years after primary LPD. Age ≤16 years at primary LPD (odds ratio [OR], 5.0), history of contralateral instability (OR, 2.4), and trochlear dysplasia (Dejour type B-D: OR, 2.5; lateral trochlear inclination ≤12°: OR, 2.7) were significant risk factors for recurrent LPD (P < .05). The prediction accuracy including these 3 risk factors was 79%. Patella alta, an increased tibial tubercle to trochlear groove distance, and patellar tilt had neither an association with increased recurrence rates nor an influence on prediction accuracy of recurrent LPD. CONCLUSION: Young age and trochlear dysplasia are major risk factors for early recurrent LPD. A multivariate model including age at primary LPD, lateral trochlear inclination, and history of contralateral LPD achieved the highest prediction accuracy. Based on these findings, the patellar instability probability calculator is proposed to estimate the individual risk of early recurrence when counseling patients after primary LPD.


Assuntos
Instabilidade Articular , Luxação Patelar , Articulação Patelofemoral , Adolescente , Estudos de Casos e Controles , Humanos , Instabilidade Articular/cirurgia , Razão de Chances , Patela/cirurgia , Luxação Patelar/epidemiologia , Articulação Patelofemoral/cirurgia , Recidiva , Estudos Retrospectivos
15.
Clin Sports Med ; 41(1): 109-121, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34782068

RESUMO

Management of the patient with multiple risk factors for recurrent patellar instability is complex. Surgeons must possess familiarity with the anatomic risk factors that are associated with first time and recurrent instability events and weigh them in the patient's individualized surgical "menu" options for surgical patellar stabilization. Addressing individual risk factors, pairing imaging findings with physical examination, and thoughts on prioritizing risk factors to determine which should be prioritized for surgical correction are discussed.


Assuntos
Instabilidade Articular , Luxação Patelar , Articulação Patelofemoral , Humanos , Instabilidade Articular/cirurgia , Luxação Patelar/diagnóstico por imagem , Luxação Patelar/epidemiologia , Luxação Patelar/cirurgia , Articulação Patelofemoral/diagnóstico por imagem , Articulação Patelofemoral/cirurgia , Recidiva , Fatores de Risco
16.
Clin Sports Med ; 41(1): 157-169, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34782072

RESUMO

Patellar instability is one of the most prevalent knee disorders, with dislocations occurring in 5 to 43 cases per 10,000 annually. Traumatic patellar dislocation can result in significant morbidity and is associated with patellofemoral chondral injuries and fractures, medial soft tissue disruption, pain, and reduced function, and can lead to patellofemoral osteoarthritis. Chronic and recurrent instability can lead to deformation and incompetence of the medial soft tissue stabilizers. Despite recent gains in understanding the pathoanatomy of this disorder, the management of patients with this condition is complex and remains enigmatic.


Assuntos
Instabilidade Articular , Luxação Patelar , Articulação Patelofemoral , Humanos , Instabilidade Articular/cirurgia , Articulação do Joelho , Ligamentos Articulares/cirurgia , Luxação Patelar/epidemiologia , Luxação Patelar/cirurgia , Articulação Patelofemoral/cirurgia
17.
PLoS One ; 16(10): e0258240, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34648534

RESUMO

BACKGROUND: Lateral patellar dislocation (LPD) frequently causes damage to the knee. Injury patterns and risk factors contributing to such injuries have not yet been examined in detail. METHODS: We retrospectively analyzed 50 consecutive patients with primary LPD. Two reviewers evaluated the MRI images regarding risk factors for LPD (Dejours classification; Caton-Deschamps Index, CDI; distance from the tibial tuberosity to trochlear groove, TT-TG; trochlear depth, TD) as well as joint damages according to the Whole-Organ Magnetic Resonance Imaging Score (WORMS). RESULTS: 33 male and 17 female patients with a mean age of 23.2 (±9.6) years were included in this study. 52% were classified Dejours ≥ B, 34% had a CDI ≥ 1.3, 22% a TT-TG ≥ 20mm and 52% a TD < 3mm. 49 out of 50 patients (98%) showed abnormalities according to WORMS. The most frequently observed abnormalities were synovitis/effusion (49/50, 98%), bone marrow oedema (44/50, 88%) and cartilage damage (42/50, 84%). Most frequently affected subregions were medial (41/50, 82%) and lateral (31/50, 62%) patella as well as the anterior (43/50, 86%), central (42/50, 84%) and posterior (11/50, 22%) portion of the lateral femoral condyle. There was no significant correlation between any of the examined risk factors and joint damages according to WORMS. Male patients had higher scores regarding total cartilage damage (5.11 vs. 2.56, p = 0.029), total score for the lateral femorotibial joint (3.15 vs. 1.65, p = 0.026) and overall total WORMS score (12.15 vs. 8.29, p = 0.038). CONCLUSION: Risk factors for LPD do not influence the risk of damages to the knee joint after primary LPD. Although LPD is generally known to affect more female than male patients, male patients suffered more severe injuries after primary LPD, particularly of the lateral femorotibial joint. Overall, our results underline the importance of MRI imaging after primary LPD.


Assuntos
Cartilagem Articular/lesões , Articulação do Joelho/patologia , Luxação Patelar/epidemiologia , Luxação Patelar/patologia , Cartilagem Articular/patologia , Feminino , Humanos , Articulação do Joelho/anormalidades , Masculino , Fatores de Risco , Adulto Jovem
18.
J Bone Joint Surg Am ; 103(22): 2126-2132, 2021 11 17.
Artigo em Inglês | MEDLINE | ID: mdl-34546985

RESUMO

BACKGROUND: Patellar instability among adolescents has an incidence of 29 to 43 per 100,000 per year. Trochlear dysplasia has been found in up to 85% of those with recurrent patellar instability. The prevalence of trochlear dysplasia in the general population has not yet been defined. The purpose of the present study was to determine the prevalence of trochlear dysplasia as defined by ultrasound in a skeletally mature population and to characterize associations of trochlear dysplasia with a history of patellofemoral instability or pain. METHODS: Skeletally mature adolescents and parents of patients (≤50 years of age) who had presented to orthopaedic clinics were prospectively enrolled from 2019 to 2020. Those presenting with knee pain, open physes, prior intra-articular fracture, total knee arthroplasty, and syndromic ligamentous laxity or neuromuscular disease were excluded. Information regarding a history of anterior knee pain, patellar instability, and/or surgery was obtained, and an abbreviated Anterior Knee Pain Scale (AKPS) was collected. An AKPS score of ≥4 was considered positive. Bilateral ultrasound of the knee was performed, and the osseous sulcus angle of the trochlea and the trochlear depth were measured. Basic descriptive statistics are reported. RESULTS: One hundred and two patients (203 knees) were studied. The mean sulcus angle was 144.1° ± 6.8°, and the mean trochlear depth was 5.5 ± 1.4 mm. High-grade trochlear dysplasia was defined as the 95th percentile and above, which was shown to be a sulcus angle of ≥154° or a trochlear depth of ≤3 mm for female patients and ≤4 mm for male patients. The prevalence of high-grade trochlear dysplasia was 5.4% based on the sulcus angle and 9.9% based on trochlear depth. Knees with high-grade trochlear dysplasia based on the sulcus angle were 11 times more likely to have had previous patellar instability (p = 0.013). CONCLUSIONS: The prevalence of high-grade trochlear dysplasia in the general population is approximately 10%, and there may be an association with patellar instability. The use of ultrasound to diagnose trochlear dysplasia may prove to be a rapid and useful tool for guiding patient education and treatment decisions. LEVEL OF EVIDENCE: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.


Assuntos
Fêmur/patologia , Instabilidade Articular/epidemiologia , Luxação Patelar/epidemiologia , Articulação Patelofemoral/patologia , Síndrome da Dor Patelofemoral/epidemiologia , Adolescente , Adulto , Feminino , Humanos , Instabilidade Articular/diagnóstico , Instabilidade Articular/etiologia , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Luxação Patelar/diagnóstico , Luxação Patelar/etiologia , Articulação Patelofemoral/diagnóstico por imagem , Síndrome da Dor Patelofemoral/diagnóstico , Síndrome da Dor Patelofemoral/etiologia , Prevalência , Estudos Prospectivos , Ultrassonografia , Adulto Jovem
19.
Unfallchirurg ; 124(11): 902-908, 2021 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-34387708

RESUMO

BACKGROUND: Numerous predisposing factors are known for patellar dislocations but the extent to which these or the trauma cause the dislocation is often unclear. AIM: This study investigated whether the analysis of the accident mechanism and anatomical predisposition in juvenile patellar dislocations enables a conclusion as to the causality. MATERIAL AND METHODS: Retrospective cohort study, evidence level III. In-house employers' liability insurance association (BG) cases with the diagnosis of patella dislocation in patients under 18 years were descriptively evaluated with respect to demographic and predisposing aspects as well as regarding accident information. The accident mechanisms were sorted into subgroups: direct impact, trivial trauma, fall, torsional trauma. RESULTS: A total of 54 patellar dislocations were identified with a patient age of 14 years (range 9-18 years). A mild valgus configuration was found in 39% of the cases, on average normal torsion, a tibial tuberosity-trochlea groove (TTTG) distance of 17 mm (range 8-24mm), with 41% a high proportion of patella alta and a trochlear deformity in 57%. Only 20% of the children had no relevant predispositions. The trivial traumas showed the highest proportion of recurrent dislocations with 50% and in the other accident categories the proportion of first dislocations was >75%. In the fall cohort the rate of children without relevant predisposition was highest. CONCLUSION: The predisposition rate in infantile patellar dislocations is high; however, falls are always significant accident events as well as medial direct impact. Torsional trauma is also a significant causative factor, unless high-grade trochlear dysplasia is present, whereas trivial traumas are not.


Assuntos
Instabilidade Articular , Luxação Patelar , Acidentes , Adolescente , Criança , Humanos , Patela , Luxação Patelar/diagnóstico por imagem , Luxação Patelar/epidemiologia , Estudos Retrospectivos , Tíbia
20.
Br J Hosp Med (Lond) ; 82(8): 1-10, 2021 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-34431342

RESUMO

Patella dislocation is one of the most common knee injuries, accounting for 3% of acute knee injuries. Despite its prevalence, patella dislocation is often missed, with a haemarthrosis often the only sign, albeit a non-specific one. A thorough history and examination are necessary to identify patella dislocation and its potential causes. Investigations should include cross-sectional imaging to evaluate both osseous and soft tissue structures in order to guide management. Management in the acute setting is normally non-operative, but damage to structural supports, osteochondral defects or recurrent dislocation should prompt consideration of operative treatment. Operative treatment should address the soft tissue stabilisers and/or osseus deformities that predispose to, or occur secondary to, patella dislocation.


Assuntos
Luxações Articulares , Traumatismos do Joelho , Luxação Patelar , Humanos , Luxações Articulares/diagnóstico por imagem , Luxações Articulares/terapia , Articulação do Joelho , Patela/diagnóstico por imagem , Luxação Patelar/diagnóstico por imagem , Luxação Patelar/epidemiologia , Prevalência
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